YWHAZ（tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta），癌症关联基因，基因ID：7534，该基因产物属于14-3-3蛋白家族，通过与含磷酸丝氨酸的蛋白质结合介导信号转导。这种高度保守的蛋白质家族在植物和哺乳动物中都有发现，这种蛋白质与小鼠、大鼠和绵羊的同源基因99%相同编码蛋白与IRS1蛋白相互作用，提示其在调节胰岛素敏感性中起作用在5’UTR中有几个不同但编码相同蛋白质的转录变体已经被鉴定为该基因[由RefSeq提供，2008年10月]This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals， and this protein is 99% identical to the mouse， rat and sheep orthologs. The encoded protein interacts with IRS1 protein， suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq， Oct 2008]。