SETDB1（SET domain bifurcated histone lysine methyltransferase 1），癌症关联基因，基因ID：9869，这个基因编码一个组蛋白甲基转移酶，它调节组蛋白甲基化、基因沉默和转录抑制。鉴于基因沉默和转录功能障碍可能在亨廷顿病的发病机制中起作用，该基因已被确定为亨廷顿病治疗的靶点已经描述了该基因的选择性剪接转录变体。[由RefSeq提供，2011年6月]This gene encodes a histone methyltransferase which regulates histone methylation， gene silencing， and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease， given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq， Jun 2011]。