IRS1（insulin receptor substrate 1），癌症关联基因，基因ID：3667，该基因编码一种由胰岛素受体酪氨酸激酶磷酸化的蛋白质该基因突变与Ⅱ型糖尿病和胰岛素抵抗易感性有关[由RefSeq提供，2009年11月]This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq， Nov 2009]。