COPS3（COP9 signalosome subunit 3），癌症关联基因，基因ID：8533，由该基因编码的蛋白质具有激酶活性，磷酸化调节参与信号转导。它磷酸化i kappa balpha、p105和c-jun，作为复合物介导磷酸化的对接位点。该基因位于17号染色体的Smith-Magenis综合征区域内。已经发现了一些编码不同亚型的转录变体。[由RefSeq提供，2015年10月]The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha， p105， and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq， Oct 2015]。