CACNA1E（calcium voltage-gated channel subunit alpha1 E），癌症关联基因，基因ID：777，电压依赖性钙通道是由α-1、α-2、β和δ亚基组成的多亚单位复合物，其比例为1:1:1。这些通道介导钙离子进入可兴奋细胞，并参与多种钙依赖过程，包括肌肉收缩、激素或神经递质释放、基因表达、细胞运动、细胞分裂和细胞死亡。该基因编码r型钙通道的α1e亚单位，该亚单位属于“高压激活”组，可能参与对信息处理重要的神经元放电模式的调节。另外，编码不同亚型的剪接转录变体已经被描述为该基因[由RefSeq提供，2011年4月]Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1， alpha-2， beta， and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells， and are also involved in a variety of calcium-dependent processes， including muscle contraction， hormone or neurotransmitter release， gene expression， cell motility， cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels， which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript va。