KLHL6（kelch like family member 6），癌症关联基因，基因ID：89857，该基因编码kelch样蛋白（klhl）家族的一个成员，参与b淋巴细胞抗原受体信号转导和生发中心b细胞成熟。编码的蛋白质包含一个N-末端宽复合物、tramrack和bric a brac（BTB）结构域，该结构域促进蛋白质结合和二聚，一个BTB和C-末端kelch（back）结构域，以及六个C-末端kelch重复结构域。这种基因的自然突变与慢性淋巴细胞白血病有关。选择性剪接导致多个转录变体。[由RefSeq提供，2017年2月]This gene encodes a member of the kelch-like (KLHL) family of proteins， which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex， tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization， a BTB and C-terminal kelch (BACK) domain， and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq， Feb 2017]。