PRKCI（protein kinase C iota），癌症关联基因，基因ID：5584，该基因编码丝氨酸/苏氨酸蛋白激酶蛋白激酶c（pkc）家族的一个成员。pkc家族至少由8个成员组成，它们是差异表达的，参与多种细胞过程。这种蛋白激酶不依赖钙和磷脂。它不被佛波酯或甘油二酯激活。这种激酶可以通过与小gtpase rab2的直接相互作用被募集到囊泡管簇（vtcs），在那里这种激酶磷酸化甘油醛-3-磷酸脱氢酶（gapd/gapdh），并在早期分泌途径中的微管动力学中发挥作用。这种激酶被认为是bcl-abl介导的抗药物诱导凋亡所必需的，因此可以保护白血病细胞免受药物诱导的凋亡。在x染色体上有一个外显子假基因。This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members， which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2， where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway.。