PTP4A3（protein tyrosine phosphatase type IVA， member 3），癌症关联基因，基因ID：11156，这个基因编码蛋白酪氨酸磷酸酶家族的一个成员。蛋白酪氨酸磷酸酶是在多种细胞过程中起调节作用的细胞信号分子。这类蛋白酪氨酸磷酸酶在小鼠体内的研究表明，它们在体内是预酰化的，这表明它们与细胞质膜有关。编码蛋白可促进细胞增殖，该基因的过度表达与肿瘤转移有关。选择性剪接导致多个转录变体。This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo， suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation， and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants.关联癌症：结直肠癌。关联化疗药物：西妥昔单抗。