PBK（PDZ binding kinase），癌症关联基因，基因ID：55872，该基因编码一种丝氨酸/苏氨酸蛋白激酶，与双特异性丝裂原活化蛋白激酶（MAPKK）家族有关。有证据表明，有丝分裂磷酸化是必需的催化活性。编码蛋白可能参与淋巴细胞的激活和支持睾丸功能，并在精子发生过程中发挥作用。这种基因的过度表达与肿瘤发生有关。选择性剪接导致多个转录变体。This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions， with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants.关联癌症：胃腺癌，非小细胞肺癌。关联化疗药物：吉非替尼。