B2M（beta-2-microglobulin），癌症关联基因，基因ID：567，该基因编码与主要组织相容性复合体（MHC）I类重链在几乎所有有核细胞的表面上发现的血清蛋白。这种蛋白主要是β-折叠片结构，在某些病理条件下可以形成淀粉样纤维。编码的抗菌蛋白在羊水中显示出抗菌活性。这种基因的突变已被证明导致高凝性低蛋白血症。This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.关联癌症：结直肠癌，皮肤黑色素瘤。关联化疗药物：纳武单抗，纳武利尤单抗，派姆单抗，帕博利珠单抗。