SGK1（serum/glucocorticoid regulated kinase 1），癌症关联基因，基因ID：6446，该基因编码丝氨酸/苏氨酸蛋白激酶，在细胞应激反应中起重要作用。这种激酶激活某些钾、钠和氯通道，提示参与调节细胞存活、神经元兴奋性和肾钠排泄等过程。这种基因的高水平表达可能导致高血压和糖尿病肾病等疾病。几个选择性剪接的转录变体编码不同的亚型已经注意到这个基因。This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium， sodium， and chloride channels， suggesting an involvement in the regulation of processes such as cell survival， neuronal excitability， and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.关联癌症：乳腺癌。关联化疗药物：阿培利司/阿博利布，SGK1-Inh。