STAG2（stromal antigen 2），癌症关联基因，基因ID：10735，该基因编码的蛋白质是黏着素复合物的一个亚单位，在细胞分裂过程中调节姐妹染色单体的分离。该基因的靶向失活导致染色单体粘聚缺陷和非整倍体，这表明粘聚素的遗传破坏是人类癌症非整倍体的原因之一。另外，还发现了编码不同亚型的剪接转录变体。The protein encoded by this gene is a subunit of the cohesin complex， which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy， suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.关联癌症：急性髓性白血病，膀胱癌，膀胱尿路上皮乳头状癌，骨尤因肉瘤，黑色素瘤。关联化疗药物：维莫非尼，威罗菲尼。