POLE（polymerase (DNA) epsilon， catalytic subunit），癌症关联基因，基因ID：5426，该基因编码DNA聚合酶epsilon的催化亚单位。这种酶参与DNA修复和染色体DNA复制。该基因突变与结直肠癌12和面部畸形、免疫缺陷、利维多和身材矮小有关。This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism， immunodeficiency， livedo， and short stature.关联癌症：结直肠癌，子宫内膜癌，多形性胶质母细胞瘤。关联化疗药物：派姆单抗，帕博利珠单抗。