NTRK3（neurotrophic receptor tyrosine kinase 3），癌症关联基因，基因ID：4916，该基因编码神经营养性酪氨酸受体激酶（NTRK）家族的一个成员。这种激酶是一种膜结合受体，通过神经营养素结合，磷酸化自身和MAPK途径的成员。通过这种激酶的信号传导导致细胞分化，并可能在感知身体位置的本体感受神经元的发育中起到作用。这种基因的突变与髓母细胞瘤、分泌性乳腺癌和其他癌症有关。一些转录变体编码不同的亚型已被发现的这个基因。This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that， upon neurotrophin binding， phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas， secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.关联癌症：乳腺癌，乳腺分泌癌，癌症，先天性纤维肉瘤，血液癌，髓母细胞瘤，乳头状甲状腺癌，小儿B细胞淋巴母细胞白血病，小儿B淋巴细胞白血病，小儿纤维肉瘤，唾液腺癌，实体瘤。关联化疗药物：克唑替尼，恩曲替尼，拉罗替尼，拉罗替尼，赛利替尼，PLX7486。