TECPR2（tectonin beta-propeller repeat containing 2），癌症关联基因，基因ID：9895，该基因编码的蛋白质是构造酶β-螺旋桨重复序列（tecpr）家族的一员，包含tecpr和色氨酸-天冬氨酸重复序列（wd重复序列）两个结构域。该基因与自噬有关，因为该基因表达水平的降低与自噬受损有关。该基因的隐性突变与遗传性痉挛性旁瘫（HSP）有关热休克蛋白的特点是进行性痉挛和瘫痪的腿。也有证据表明该基因突变与鸟瞰性脉络膜视网膜病变（bscr）有关，后者导致脉络膜和视网膜的炎症。选择性剪接导致编码不同亚型的多个转录变体[由RefSeq提供，2015年8月]The protein encoded by this gene is a member of the tectonin beta-propeller repeat-containing (TECPR) family， and contains both TECPR and tryptophan-aspartic acid repeat (WD repeat) domains. This gene has been implicated in autophagy， as reduced expression levels of this gene have been associated with impaired autophagy. Recessive mutations in this gene have been associated with a hereditary form of spastic paraparesis (HSP). HSP is characterized by progressive spasticity and paralysis of the legs. There is also some evidence linking mutations in this gene with birdshot chorioretinopathy (BSCR)， which results in inflammation of the choroid and 。