SMAD7（SMAD family member 7），癌症关联基因，基因ID：4092，这个基因编码的蛋白质是一种结合E3泛素连接酶Smurf2的核蛋白。结合后，这种复合物转移到细胞质中，在细胞质中与tgfβ受体1（tgfbr1）相互作用，导致编码蛋白和tgfbr1降解。TGFBR1可诱导该基因的表达这种基因的变异是结直肠癌3型（crcs3）易感性的一个原因。已经发现了一些编码不同亚型的转录变体。[由RefSeq提供，2010年6月]The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding， this complex translocates to the cytoplasm， where it interacts with TGF-beta receptor type-1 (TGFBR1)， leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq， Jun 2010]。