PIK3C2A（phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha），癌症关联基因，基因ID：5286，该基因编码的蛋白属于磷酸肌醇3激酶（PI3K）家族pi3激酶在参与细胞增殖、癌基因转化、细胞存活、细胞迁移和细胞内蛋白质转运的信号传导途径中发挥作用。该蛋白包含一个脂质激酶催化结构域和一个C末端C2结构域，这是II类PI3激酶的特征C2结构域作为钙依赖性磷脂结合基序，介导蛋白质向膜的转运，也可能介导蛋白质-蛋白质的相互作用。该蛋白的pi3激酶活性对抑制剂wortmanin的纳摩尔水平不敏感。该蛋白能被胰岛素激活，可能参与整合素依赖信号传导。[由RefSeq提供，2008年7月]The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation， oncogenic transformation， cell survival， cell migration， and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain， a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes， and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not s。