NOD1（nucleotide binding oligomerization domain containing 1），癌症关联基因，基因ID：10392，该基因编码核苷酸结合寡聚结构域（nod）样受体（nlr）家族的一个成员。编码蛋白作为结合细菌肽聚糖并引发炎症的模式识别受体（prr）在先天免疫中发挥作用。这种蛋白质也与病毒和寄生虫感染的免疫反应有关。该蛋白的主要结构特征包括一个n端caspase募集域（card）、一个中心定位的核苷酸结合域（nbd）和其c端的10个富含亮氨酸的串联重复序列（lrrs）。card参与凋亡信号传导，lrrs参与蛋白质-蛋白质相互作用，nbd突变可能影响lrr结构域的齐聚过程和随后的功能。该基因突变与人类哮喘、炎症性肠病、白塞病和结节病有关[由RefSeq提供，2017年8月]This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD)， a centrally located nucleotide-binding domain (NBD)， and 10 tandem leucine-rich repeats (LRRs) in its C ter。