MNDA（myeloid cell nuclear differentiation antigen），癌症关联基因，基因ID：4332，髓样细胞核分化抗原（mnda）仅在粒单核细胞系的细胞核中检测到。人类MNDA的200个氨基酸区域与干扰素诱导的小鼠基因家族（指定为Ifi-201、Ifi-202和Ifi-203）编码的蛋白质中的一个区域惊人地相似，这些基因不以细胞或组织特异性方式调节1.8-kb的mnda mrna在5-原代未翻译区含有干扰素刺激的应答元件，在暴露于干扰素α的人单核细胞中显著上调。MNDA位于FCER1A、APCS、CRP和SPTA1的2200 kb范围内在其表达和/或调节模式中，MNDA类似于IFI16，表明这些基因参与了血细胞对干扰素的特异性反应[由RefSeq提供，2008年7月]The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes， designated Ifi-201， Ifi-202， and Ifi-203， that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA， which contains an interferon-stimulated response element in the 5-prime untranslated region， was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within。