KDM2B（lysine demethylase 2B），癌症关联基因，基因ID：84678，该基因编码的F盒蛋白家族的成员，其特征在于约40个氨基酸基序，F盒。F-box蛋白是泛素蛋白连接酶复合物SCFs（SKP1-cullin-F-box）的四个亚基之一，在磷酸化依赖性泛素化中发挥作用f-box蛋白分为3类：含wd-40结构域的fbws、含富含亮氨酸重复序列的fbls和含不同蛋白相互作用模块或无可识别基序的fbxs。这个基因编码的蛋白质属于fbls类。已发现该基因的多个选择性剪接转录变体，但尚未确定某些变体的全长性质[由RefSeq提供，2008年7月]This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif， the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box)， which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains， Fbls containing leucine-rich repeats， and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this g。