DNAH1（dynein axonemal heavy chain 1），癌症关联基因，基因ID：25981，这个基因编码一个内动力蛋白臂重链，它在精子尾部的外双峰和桡骨辐条之间提供结构支持。该基因的自然突变与原发性纤毛运动障碍和鞭毛的多种形态异常有关，导致弱精子症和男性不育。同源基因纯合子敲除的小鼠是活的，但精子活力降低，不育。[由RefSeq提供，2017年2月]This gene encodes an inner dynein arm heavy chain that provides structural support between the radial spokes and the outer doublet of the sperm tail. Naturally occurring mutations in this gene are associated with primary ciliary dyskinesia and multiple morphological anomalies of the flagella that result in asthenozoospermia and male infertility. Mice with a homozygous knockout of the orthologous gene are viable but have reduced sperm motility and are infertile. [provided by RefSeq， Feb 2017]。