DENND1A（DENN domain containing 1A），癌症关联基因，基因ID：57706，氯氰菊酯（见mim 118955）介导的内吞作用是蛋白质和脂类内化的主要机制。connecdenn家族的成员，如dennd1a，对早期的小gtpase rab35（mim 604199）起鸟嘌呤核苷酸交换因子（gefs）的作用，并与氯菊酯和氯菊酯衔接蛋白-2（ap2；见mim 601024）结合。因此，Connecdens将RAB35激活与氯氰菊酯机械联系起来（Marat和Mcpherson，2010【PubMed 20154091】。【OMIM提供，2010年11月】Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family， such as DENND1A， function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus， connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson， 2010 [PubMed 20154091]).[supplied by OMIM， Nov 2010]。