CYP1A1（cytochrome P450 family 1 subfamily A member 1），癌症关联基因，基因ID：1543，这个基因，cyp1a1，编码细胞色素p450酶超家族的一个成员。细胞色素p450蛋白是一种单加氧酶，催化药物代谢和胆固醇、类固醇等脂类的合成。这种蛋白质定位于内质网，其表达是由一些多环芳烃（pahs）诱导的，其中一些存在于香烟烟雾中。该酶的内源底物尚不清楚，但它能将一些多环芳烃代谢为致癌中间体。这种基因与肺癌的风险有关。相关的家族成员CYP1A2位于15号染色体上的CYP1A1约25 kb处。选择性剪接导致编码不同亚型的多个转录变体。[由RefSeq提供，2016年1月]This gene， CYP1A1， encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol， steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs)， some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however， it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member， CYP1A2， is located ap。