CLP1（cleavage factor polyribonucleotide kinase subunit 1），癌症关联基因，基因ID：10978，这个基因编码Clp1家族的一个成员编码蛋白是一种多功能激酶，是trna剪接核酸内切酶复合物的组成部分和前mrna切割复合物ii的组成部分。这种蛋白与trna、mrna和sirna成熟有关。该基因突变与桥小脑发育不全10型（PCH10）有关另外，已经发现该基因编码不同亚型的剪接转录变体。[由RefSeq提供，2014年9月]This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA， mRNA， and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq， Sep 2014]。