CLK2（CDC like kinase 2），癌症关联基因，基因ID：1196，该基因编码一种双特异性蛋白激酶，磷酸化丝氨酸/苏氨酸和酪氨酸底物。该蛋白的活性调节剪接体复合体中富含丝氨酸和精氨酸（SR）的蛋白质，从而影响选择性转录剪接。该位点与19号染色体上的pafah1b3（血小板活化因子乙酰水解酶1b，催化亚单位3（29kDa））基因之间的染色体易位已经被证实，从而产生了融合蛋白。注意，该基因与telo2基因（geneid:9894）不同，后者共享clk2别名，但编码一种参与端粒长度调节的蛋白质。在7号染色体上有一个假基因。选择性剪接导致多个转录变体[由RefSeq提供，2014年6月]This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex， thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b， catalytic subunit 3 (29kDa)) gene on chromosome 19， resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894)， which shares the CLK2 alias， but encodes a protein that is invol。