AGAP3(ArfGAP with GTPase domain, ankyrin repeat and PH domain 3),癌症关联基因,基因ID:116988,该基因编码n-甲基-d-天冬氨酸(nmda)受体信号复合物的一个重要组成部分,该复合物通过将nmda受体的激活与α-氨基-3-羟基-5-甲基-4-异恶唑雷波酸(ampa)受体的转运联系起来,介导突触中的长期增强。编码蛋白包含一个N端GTPase样结构域、一个pleckstrin同源结构域、一个ArfGAP结构域和几个C端ankryn重复结构域[由RefSeq提供,2017年4月]This gene encodes an essential component of the N-methyl-D-aspartate (NMDA) receptor signaling complex which mediates long-term potentiation in synapses by linking activation of NMDA receptor to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking. The encoded protein contains an N-terminal GTPase-like domain, a pleckstrin homology domain, an ArfGAP domain and several C-terminal ankryn repeat domains. [provided by RefSeq, Apr 2017]。