MECOM（MDS1 and EVI1 complex locus），癌症关联基因，基因ID：2122，该基因编码的蛋白是一种转录调节因子和肿瘤蛋白，可能参与造血、凋亡、发育、细胞分化和增殖。编码蛋白可与ctbp1、smad3、crebbp、kat2b、mapk8和mapk9相互作用。该基因可与aml1基因发生易位，导致该基因的过度表达和白血病的发生。已经发现了一些编码一些不同亚型的转录变体。[由RefSeq提供，2011年3月]The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis， apoptosis， development， and cell differentiation and proliferation. The encoded protein can interact with CTBP1， SMAD3， CREBBP， KAT2B， MAPK8， and MAPK9. This gene can undergo translocation with the AML1 gene， resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq， Mar 2011]。