GLI3（GLI family zinc finger 3），癌症关联基因，基因ID：2737，该基因编码一种属于gli家族c2h2型锌指蛋白亚类的蛋白质。它们具有dna结合转录因子的特性，是声刺猬（shh）信号传导的介质。该基因编码的蛋白质定位在细胞质中，激活果蝇同源基因（ptch）的表达。它也被认为在胚胎发生过程中起作用。该基因的突变与多种疾病相关，包括GRIG头-头多指畸形综合征、帕利斯特-霍尔综合征、前轴多指肌腱Ⅳ型和后轴多指型A1和B型[由RefSeq，Jul 2008提供]。This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases， including Greig cephalopolysyndactyly syndrome， Pallister-Hall syndrome， preaxial polydactyly type IV， and postaxial polydactyly types A1 and B. [provided by RefSeq， Jul 2008]。