PRKCB（protein kinase C beta），癌症关联基因，基因ID：5579，蛋白激酶C（PKC）是一个丝氨酸和苏氨酸特异性蛋白激酶家族，可被钙和第二信使二酰甘油激活。pkc家族成员磷酸化多种蛋白质靶点，已知参与多种细胞信号传导途径。PKC家族成员也作为一类肿瘤启动子佛波酯的主要受体。pkc家族的每一个成员都有一个特定的表达谱，并且被认为在细胞中起着独特的作用。该基因编码的蛋白质是pkc家族成员之一。据报道，这种蛋白激酶参与多种不同的细胞功能，如B细胞活化、凋亡诱导、内皮细胞增殖和肠道糖吸收。对小鼠的研究也表明，这种激酶还可能调节神经元功能，并与压力后恐惧诱导的冲突行为相关。另外还报道了编码不同亚型的剪接转录变体。Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters， a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many d。