PDGFB（platelet derived growth factor subunit B），癌症关联基因，基因ID：5155，该基因编码由血小板衍生生长因子（PDGF）和血管内皮生长因子（VEGF）组成的蛋白家族成员。编码的前蛋白经蛋白质水解处理产生血小板衍生生长因子B亚单位，该亚单位可与相关的血小板衍生生长因子A亚单位同二聚或异二聚。这些蛋白结合并激活pdgf受体酪氨酸激酶，在广泛的发育过程中发挥作用。该基因的突变与脑膜瘤有关。染色体22和17之间的相互易位，在这个基因和胶原1型α1的位置，与一种罕见的皮肤肿瘤——皮肤纤维肉瘤突起有关。选择性剪接导致多个转录变体。This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B， which can homodimerize， or alternatively， heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases， which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17， at sites where this gene and that for colla。