MEN1（menin 1），癌症关联基因，基因ID：4221，这个基因编码脑膜，一种与多发性内分泌肿瘤1型综合征相关的假定的肿瘤抑制因子。体外研究表明，脑膜定位于细胞核，具有两种功能性核定位信号，并通过JUND抑制转录激活，但这种蛋白的功能尚不清楚。在Northern blots上检测到两条信息，但未对较大的信息进行描述。选择性剪接导致多个转录变体。This gene encodes menin， a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus， possesses two functional nuclear localization signals， and inhibits transcriptional activation by JunD， however， the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants.关联癌症：甲状腺损伤细胞癌。