SNAI2（snail family transcriptional repressor 2），癌症关联基因，基因ID：6591，该基因编码c2h2型锌指转录因子蜗牛家族的一个成员。编码蛋白作为一种转录抑制因子，与e-box基序结合，也可能抑制乳腺癌中e-cadherin的转录。该蛋白参与上皮-间质转化，具有抗凋亡活性该基因突变可能与神经管缺陷的孢子状病例有关。[由RefSeq提供，2008年7月]This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq， Jul 2008]。