SF1（splicing factor 1），癌症关联基因，基因ID：7536，这个基因编码一个核前mrna剪接因子。编码的蛋白质在3’剪接位点特异性地识别内含子分支点序列，以及U2辅助因子（U2AF）的大亚基，并且对于剪接体组装的早期阶段是必需的。它也在核前mrna保留和转录抑制中发挥作用。编码的蛋白质包含一个N端U2AF配体基序、一个中心HNRNP K同源基序和一个与支点序列内的关键支点腺苷、一个锌指关节结构域和一个富含脯氨酸的C端结构域结合的震动2区。选择性剪接导致多个转录变体[由RefSeq提供，2016年10月]This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site， together with the large subunit of U2 auxiliary factor (U2AF)， and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif， a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence， a zinc knuckles domain， and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided 。