SESN1（sestrin 1），癌症关联基因，基因ID：27244，这个基因编码一个sestrin家族的成员SSTRIN是由p53肿瘤抑制蛋白诱导的，并在细胞对DNA损伤和氧化应激的反应中起作用。编码蛋白通过激活amp激活的蛋白激酶介导p53对细胞生长的抑制，从而抑制雷帕霉素蛋白的哺乳动物靶点。编码过氧化过氧化还原酶的蛋白质也在抗氧化防御中起着关键作用，该基因的表达是辐射暴露的潜在标志物。另外，已经观察到该基因编码多个亚型的剪接转录变体[由RefSeq提供，2010年12月]This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase， which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins， and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq， Dec 2010]。