PRKCA（protein kinase C alpha），癌症关联基因，基因ID：5578，蛋白激酶C（PKC）是一个丝氨酸和苏氨酸特异性蛋白激酶家族，可被钙和第二信使甘油二酯激活pkc家族成员磷酸化多种蛋白质靶点，参与多种细胞信号传导途径。PKC家族成员也是一类肿瘤促进剂佛波酯的主要受体pkc家族的每个成员都有一个特定的表达谱，并被认为在细胞中发挥着独特的作用。该基因编码的蛋白是pkc家族成员之一。据报道，这种激酶在许多不同的细胞过程中发挥作用，如细胞粘附、细胞转化、细胞周期检查点和细胞体积控制。小鼠的基因敲除研究表明，这种激酶可能是心肌细胞收缩力和钙离子处理的基本调节因子。[由RefSeq提供，2008年7月]Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters， a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different ce。