H2AX（H2A.X variant histone），癌症关联基因，基因ID：3014，组蛋白是构成真核生物染色体纤维核小体结构的基本核蛋白四个核心组蛋白（H2A、H2B、H3和H4）中的每一个分子形成一个八聚体，其中大约146 bp的DNA被包裹在被称为核小体的重复单元中。连接组蛋白H1在核小体之间与连接DNA相互作用，在染色质压缩成高阶结构中发挥作用该基因编码组蛋白H2A家族成员中一个与复制无关的组蛋白，并通过保守的茎环终止基序和polyA加合基序产生两个转录本[由RefSeq提供，2015年10月]Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A， H2B， H3， and H4) form an octamer， around which approximately 146 bp of DNA is wrapped in repeating units， called nucleosomes. The linker histone， H1， interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family， and generates two transcripts through the use of the conserved stem-loop termination motif， and the polyA addition motif. [provided by RefSeq， Oct。