CYP2E1（cytochrome P450 family 2 subfamily E member 1），癌症关联基因，基因ID：1571，该基因编码细胞色素P450酶超家族的一个成员细胞色素p450蛋白是一种单加氧酶，催化药物代谢和胆固醇、类固醇等脂类的合成。这种蛋白质定位于内质网，由乙醇、糖尿病状态和饥饿诱导。这种酶既能代谢内源性底物，如乙醇、丙酮和缩醛，也能代谢外源性底物，如苯、四氯化碳、乙二醇和亚硝胺，这些都是香烟烟雾中的前突变物。由于其底物众多，这种酶可能参与糖异生、肝硬化、糖尿病和癌症等多种过程[由RefSeq提供，2008年7月]This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol， steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol， the diabetic state， and starvation. The enzyme metabolizes both endogenous substrates， such as ethanol， acetone， and acetal， as well as exogenous substrates including benzene， carbon tetrachloride， ethylene glycol， and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates， this enzyme may be involved in such varied proces。