COL15A1（collagen type XV alpha 1 chain），癌症关联基因，基因ID：1306，这个基因编码XV型胶原的α链，它是FACIT胶原家族的一员（与纤维相关的具有间断螺旋的胶原）xv型胶原具有广泛的组织分布，但最强的表达定位于基底膜区，因此它可能起到将基底膜粘附到下层结缔组织基质的作用。蛋白水解产生的xv型胶原c末端片段是restin，一种潜在的抗血管生成蛋白，与内皮抑素密切相关。小鼠研究表明，胶原XV缺乏与肌肉和微血管恶化有关[由RefSeq提供，2013年5月]This gene encodes the alpha chain of type XV collagen， a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin， a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq， May 2013]。