BRWD1（bromodomain and WD repeat domain containing 1），癌症关联基因，基因ID：54014，这个基因编码WD重复蛋白家族的一个成员。WD重复是大约40个氨基酸的最小保守区域，通常由GLY HIT和Trp ASP（GH-WD）残基包围，这可能促进异源三聚体或多蛋白复合物的形成。该家族成员参与多种细胞过程，包括细胞周期的进展、信号转导、凋亡和基因调控。该蛋白含有2个溴脱氧核糖和多个WD重复序列该基因位于21号染色体唐氏综合征2区。该基因的选择性剪接产生编码不同亚型的多个转录变体在小鼠中，该基因编码一种核蛋白，该核蛋白含有多聚谷氨酸，作为一个转录激活域，可以调节染色质重塑，并与swi/snf染色质重塑复合物的一个成分相关联。[由refseq提供，2011年6月]This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression， signal transduction， apoptosis， and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this。