ARFGEF1（ADP ribosylation factor guanine nucleotide exchange factor 1），癌症关联基因，基因ID：10565，adp-核糖化因子（arfs）在细胞内囊泡转运中起重要作用。该基因编码的蛋白通过加速gtp替代结合的gdp参与arfs的激活。它包含一个Sec7结构域，可能负责鸟嘌呤核苷酸交换活性和布雷菲尔德a抑制作用[由RefSeq提供，2011年8月]ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain， which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq， Aug 2011]。