ADH1B（alcohol dehydrogenase 1B (class I)， beta polypeptide），癌症关联基因，基因ID：125，这个基因编码的蛋白质是乙醇脱氢酶家族的一员。这种酶家族的成员代谢多种底物，包括乙醇、视黄醇、其他脂肪醇、脂肪醇和脂质过氧化产物。该编码蛋白由α、β和γ亚基的多个同源异构体和异二聚体组成，对乙醇氧化具有高活性，在乙醇分解代谢中起重要作用。编码α、β和γ亚单位的三个基因以基因簇的形式排列在基因组片段中已经发现了两个编码不同亚型的转录变体。[ RefSeq，2013月11日]The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates， including ethanol， retinol， other aliphatic alcohols， hydroxysteroids， and lipid peroxidation products. This encoded protein， consisting of several homo- and heterodimers of alpha， beta， and gamma subunits， exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha， beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq， Nov 2013]。