BUB1B（BUB1 mitotic checkpoint serine/threonine kinase B），癌症关联基因，基因ID：701，这个基因编码一个参与纺锤体检查点功能的激酶。该蛋白已定位于动粒，并在抑制后期促进复合物/环小体（apc/c）中发挥作用，延缓后期的发生，确保染色体的正确分离。纺锤体检查点功能受损已在多种癌症中发现。[由RefSeq提供，2008年7月]This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C)， delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq， Jul 2008]。