PRSS8（serine protease 8），癌症关联基因，基因ID：5652，该基因编码丝氨酸蛋白酶的肽酶s1或糜蛋白酶家族的一个成员。编码的前蛋白通过蛋白质水解产生轻链和重链，通过二硫键结合形成异二聚体酶。这种酶在前列腺上皮中高度表达，是在精液中发现的几种蛋白水解酶之一。这种蛋白酶具有胰蛋白酶样底物特异性，在赖氨酸或精氨酸残基的羧基末端切割蛋白质底物。编码的蛋白酶部分介导上皮钠通道（钠平衡的调节者）的蛋白水解酶激活，并可能在上皮屏障形成中发挥作用。[由RefSeq提供，2016年2月]This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity， cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel， a regulator of sodium balance， and may also play a role in epithelial barrier formation.。