RAD23B（RAD23 homolog B， nucleotide excision repair protein），癌症关联基因，基因ID：5887，该基因编码的蛋白质是酿酒酵母RAD23（一种参与核苷酸切除修复（NER）的蛋白质）的两个人类同系物之一。这种蛋白被发现是蛋白复合物的一个组成部分，它在体外专门补充着色性干皮病C组（xp-c）细胞提取物的NER缺陷。该蛋白还与3-甲基腺嘌呤-DNA糖基化酶（MPG）的核苷酸切除活性相互作用，并提高其活性，提示其在碱基切除修复中的DNA损伤识别作用。这种蛋白含有一个N端泛素样结构域，据报道与26S蛋白酶体相互作用，因此这种蛋白可能参与细胞中泛素介导的蛋白水解途径。选择性剪接导致编码不同亚型的多个转录变体。The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23， a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with， and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG)， which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain， which was reported to i。