POLD1（polymerase (DNA) delta 1， catalytic subunit），癌症关联基因，基因ID：5424，该基因编码DNA聚合酶δ的125kDa催化亚单位。DNA聚合酶三角洲既具有聚合酶活性，又具有3-5'外切酶活性，在DNA复制和修复中起着关键作用。另外还观察到该基因的剪接转录变体，该基因的假基因位于6号染色体的长臂上。This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene， and a pseudogene of this gene is located on the long arm of chromosome 6.关联癌症：肺腺癌，非小细胞肺癌。关联化疗药物：派姆单抗，帕博利珠单抗。