MSH2（mutS homolog 2），癌症关联基因，基因ID：4436，该基因座在遗传性非息肉性结肠癌（HNPCC）中经常发生突变。克隆时，发现它是大肠杆菌错配修复基因muts的人类同源物，与在hnpcc中发现的微卫星序列（rer+表型）的特征性变化一致。两个编码不同亚型的转录变体已经被发现。This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned， it was discovered to be a human homolog of the E. coli mismatch repair gene mutS， consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.关联癌症：林奇综合征，尿路上皮癌。关联化疗药物：MEDI0680，度伐利尤单抗，德瓦鲁单抗。