RRM1（ribonucleotide reductase catalytic subunit M1），癌症关联基因，基因ID：6240，这个基因编码核糖核苷酸还原酶的大的催化亚单位，这是一种将核糖核苷酸转化为脱氧核糖核苷酸所必需的酶。在细胞周期的S阶段以及多个DNA修复过程中，可用的脱氧核糖核苷酸池对DNA复制很重要。选择性剪接导致多个转录变体。This gene encodes the large and catalytic subunit of ribonucleotide reductase， an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants.关联癌症：非小细胞肺癌，胰腺癌。关联化疗药物：Cisplatine，PLATINUM。