马克斯普朗克生物物理研究所（Max Planck Institute of Biophysics）,地址：德国,德国；It is estimated that between 30 and 40% of all cellular proteins reside in the non-aqueous environment of lipid membranes where they perform crucial metabolic functions and regulate the transfer of information and material into and out of the cell. Because membrane proteins govern such processes as nutrient uptake, drug efflux, respiration, sensory physiology, endocrine function, immunity and neuronal communication, they are central players in numerous disease states and host-pathogen interactions. To understand and modulate any of these processes, a thorough understanding of the activities of the respective membrane protein components – at the molecular level – is an absolute requirement.However, their location in hydrophobic membranes presents extreme difficulties for their isolation and characterization, with the result that k。