YBX1（Y-box binding protein 1），癌症关联基因，基因ID：4904，该基因编码一种高度保守的冷休克蛋白，具有广泛的核酸结合特性。编码蛋白作为一种dna和rna结合蛋白，参与多种细胞过程，包括转录和翻译调控、mrna前剪接、dna修复和mrna包装。该蛋白也是信使核糖核蛋白（mrnp）复合物的组成部分，可能在microrna加工中起作用。这种蛋白可以通过非经典途径分泌，并作为细胞外有丝分裂原发挥作用。该基因的异常表达与许多组织中的癌症增殖有关。该基因可能是某些癌症预后差和耐药的一个预后标志。交替剪接导致多个转录变体。该基因的假基因存在于多条染色体上。[由RefSeq提供，2015年9月]This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation， pre-mRNA splicing， DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferati。