TBX22（T-box transcription factor 22），癌症关联基因，基因ID：50945，这个基因是一个系统学保守的基因家族的成员，该家族共享一个共同的DNA结合域T-boxT-box基因编码参与发育过程调控的转录因子该基因突变与遗传性x连锁疾病（腭裂伴舌苔强直）有关，并被认为在人类腭裂发生中起主要作用。另外，已经发现该基因编码不同亚型的剪接转录变体[由RefSeq提供，2008年7月]This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain， the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder， Cleft palate with ankyloglossia， and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq， Jul 2008]。